Cirrhosis

Cirrhosis is a chronic diffuse irreversible liver disease characterized by:
-progressive necrosis of liver cells in all lobus,associated with distruction of the reticulum framework of liver
-repair by both regeneration(in the form of nodules) and fibrosis
-restoration of the normal liver function does not occur since the regeneration nodules have no regular relation to portal tracts,no or eccentric veins and irregular sinusoids.
Types of cirrhosis:
1.Nutritional and Alcoholic Cirrhosis.chronic alcoholism or prolonged severe malnutrition lead to steatosis fallowed by gradual progressive liver cells loss and cirrhosis.
2.Post hepatic Cirhosis.It fallows chronic active hepatitis.It is a mixed micro and macronodular cirrhosis.
3.Post necrotic Cirrhosis.It is a rare type fallowing diffuse liver necrosis(do to viral or toxic hepatitis caused by drugs or isoniazid or chemicals as carbon tetrachloride0.It is a macronodular cirrhosis.
4.Primary biliary cirrhosis.This is an autoimmune disease that mostly affects middle age females.In 95% of cases serum M antibodies are detected.
5.Secondary biliary Cirrhosis.
6.Cirrhosis caused by congenital metabolic disorders
7.Cirrhosis related to circulatory disorders
8.Indian Chialdhood Cirrhosis.
9.Cryptogenic cirrhosis
10.Other causes(rare):congenital syphilis,ulcerative colitis...